Your question is so vague that it's nearly impossible to answer.
Please consider providing basic information about your setup.
Describe your FreeNAS system. This includes stuff like what sort of system it is ("TrueNAS R50" means nothing to most of the posters here --including me), what sort of CPU, how much memory, what kind of storage, how the storage pool is laid out, what sort of network controller, the network design, etc.
Describe your Veeam server and the role it is playing. Is it a bare metal Veeam proxy? Why are you using iSCSI instead of CIFS? Do you have problems if you use CIFS, which is the normal way for a Veeam proxy to access network attached storage?
You're presumably backing up PC's or virtual machines. Some brief explanation there might be helpful.
I have a suspicion that you're using RAIDZ and iSCSI; this is a match made in hell, in my experience. Specific discussion at this linked article:
https://www.truenas.com/community/threads/the-path-to-success-for-block-storage.81165/
If you are trying to use REFS/NTFS on top of iSCSI on top of RAIDZ so that you get the "benefits", it probably won't work out that way.