@SeaWolfX - Maybe this summary can make things clearer: The Supermicro (or other server-grade motherboards) are made for the data centre - 24x7 usage, minimal downtime for 4, 5, 6 or more years. Because server-grade motherboards (or full servers) need to meet these needs, they have built-in compensating controls like ECC memory, redundant power supplies, remote management (e.g., IPMI), etc. Of course, you have to pay for this and that is where buying a "previously loved" server comes into play. But, another caveat, they are made for the data centre and where noise (read: fans) are not all that important. (At my organization you need to wear ear protection in the data centre to comply with OH&S.) While AMD is moving up (seemingly quickly with some rather great hardware - EPYC) Intel Xeon's have been standard for years. They just work.
The other consideration is that TrueNAS (more so now with FreeNAS and TrueNAS converging) is the operating environment for Ixsystems' data centre-grade equipment. That means that the number of permutations of hardware are smaller; that is coupled with the relative base of FreeBSD v. Linux OSes deployed means there are less tested and/or support components.
So, where does that you (me/us)? It depends upon your risk tolerance. For me, while I only use TrueNAS for home use, my photos, documents, etc. are important enough to settle on "previously" loved server gear. I have my rack set up so that *most* of the fan noise is contained (e.g., I can live with it in my home office and replacing the stock Supermicro fans with quieter Nocturas isn't an option because server chassis depend on airflow - CFM - and air pressure - in Hg) and I make sure that I back everything up to different storage locations (e.g., a different NAS at home and an offsite storage pool).
If you want something that doesn't need constant care and attention (outside "normal" stuff like updates, backups, etc.) then chose components that are known to word; e.g., Supermicro motherboards, Xeon (or i3) CPUs, ECC RAM, LSI HBA (in IT mode!), etc. There are a lot of threads and resources on the forum that will help you make your choices. You will get the benefit as well of IPMI (and once you start using it you'll like it - NOTE: Try to get a motherboard that uses HTML and not Java for IMPI remote console).
If you want to experiment then, as we say here - fill your boots. But you may be alone in trying to figure out why component X won't work as you may be the only one trying it.
Good luck!
Mike