Damage to a single vdev is damage to the pool, so for example three mirror vdevs in one zpool is single redundancy -- two drives dieing can kill that pool (it won't if the drives are part of different mirrors, but it will if both drives are in the same mirror).
Now, that's the way I ran my home server since 2006 -- started with one mirror, added a second mirror, then a third, then upgraded the disks in the first, etc. The biggest of those disks was 2TB, I was willing to go with single redundancy for that (I also had backups, including offsite).
For a bigger chunk of storage, of course RAIDZ is more efficient. A 4+2 pool (RAIDZ2 on 6 disks) has double redundancy, it can withstand the failure of
any two drives in the array, so that's safer than the same 6 disks arranged in three mirrors. However, the three mirrors setup is more flexible and easier to upgrade -- the three mirrors can be different sizes, and a mirror can be upgraded without ever lowering the redundancy, whereas a RAIDZ cannot. So...tradeoffs.
As the number of disks starts hitting the number of physical or controller slots in your host, the efficiency of RAIDZ becomes more attractive

. I'm now in the process of re-working the physical chassis of my original server to also contain a big array for off-site backup for my partner in the video business; the backup array will be 8+3 of 6TB drives. I've managed to make room both physically and on the disk controllers for 14 drives total, which leaves me replacing my 3 two-way mirrors with just three drives; I'm going to do that as a three-way mirror of 6TB drives, because with drives that big single redundancy just doesn't cut it (resilver time is so long, and of course that increases stress on the rest of the array, that something else might go!).
There are modest space gains from making the base size of a RAIDZ array (before adding parity disks) a power of 2; hence I'm going with 2, 4, and 8-disk base arrays. Not actually using any 2-disk arrays; I was going to do a 2+2 for my production array, but with disk sizes so big today, a three-way mirror gets me sufficient redundancy and sufficient size in just three drives, allowing me to add a third parity disk to the 8-disk array, which really needed it. Anyway -- a 6+2 array won't give you quite the space you expected, is the point here.