First problem, the ioSafe Duo has a hardware RAID controller. Even if you re-configure it to be JBOD, it's likely that still hides SMART and direct disk access from the host server.
Next, USB is generally not a robust protocol for storage, unlike SAS & SATA. USB has gotten better, especially if you use higher speed connections, (like this ioSafe Duo), and if the device supports UASP, (USB Attached SCSI Protocol). But, we still discourage data disk connections via USB. (Temporary backup disks via USB can work...)
To continue, OpenZFS tends to push TONS of data through in a short time. Either writing it's transaction groups, performing pool scrubs or performing ZFS Send / Receives for backups. This tends to find corner cases and odd flaws in disk connections. SAS & SATA tends to be better, though can also be impacted by this if using cheaper, or less well tested disk host bus controllers.
Last, since this is a USB device, it may very well hide the attached disk's serial numbers. Thus, confusing the host server in determining which disk is which. So the TrueNAS server might think it has 2 paths to the same disk. (Which could lead to pool corruption very quickly.)