Here's a quote from the manual "If you plan to use ZFS deduplication, ensure you have at least 5 GB RAM per TB of storage to be deduplicated."
Many users don't heed this advice and end up in trouble. Two weeks ago we had a fellow that ran into this problem. He had to task his hard disks to work in order to find a machine that had sufficient RAM to load his pool. He didn't discover the problem until he shut his server down and couldn't bring it back up.