When will this line finally die? There is no RAMdisk or similar thing. The OS is loaded like any other. Sure, ARC helps, but the boot device is not virtually read-only.
A slow boot device can easily render the GUI useless as components fail to load. And boot environment manipulations get rather long and painful. And so on...
My point is that there is real value in going with a real SSD instead of USB flash drives. Cheap M.2 PCIe SSDs can fill the niche previously occupied by expensive, unreliable SATA DOMs.