It should work as M.2 has SATA lanes, so driver should be present under 9.3.
It would definitely be faster, but is it that much of a benefit, probably not unless you host the reporting Database vs. USB.
You may not be able to mirror the boot drive as only one M.2 interface is most likely available. I don't know if redundancy will work between USB and M.2 (it should for ZFS).