See the attached first two files for how I have it set up in the GUI. 
Code:
root@plexmediaserver_1:/ # ifconfig											
lo0: flags=8049<UP,LOOPBACK,RUNNING,MULTICAST> metric 0 mtu 16384			  
		options=600003<RXCSUM,TXCSUM,RXCSUM_IPV6,TXCSUM_IPV6>				  
		inet6 ::1 prefixlen 128												
		inet6 fe80::1%lo0 prefixlen 64 scopeid 0x1							
		inet 127.0.0.1 netmask 0xff000000									  
		nd6 options=21<PERFORMNUD,AUTO_LINKLOCAL>							  
epair0b: flags=8843<UP,BROADCAST,RUNNING,SIMPLEX,MULTICAST> metric 0 mtu 1500  
		options=8<VLAN_MTU>													
		ether 0x:fx:7x:0x:0x:0x												
		inet 10.0.100.155 netmask 0xffffff00 broadcast 10.0.100.255			
		inet6 2601:401:xxx:xxxx:: prefixlen 64 tentative					  
		nd6 options=9<PERFORMNUD,IFDISABLED>								  
		media: Ethernet 10Gbase-T (10Gbase-T <full-duplex>)					
		status: active
 
Are you suggesting I set IP, gateway, and NS from the shell?